The test has been developed as an alternate to the present prevalent practice of monitoring blood sugar, which may be invasive, painful and dear.
Lab tests of the saliva process had an accuracy rate of 95.2%. The research shows promising results for monitoring diabetes, which affects an estimated 425 million people worldwide – around half them undiagnosed.
The research has been published within the journal PLOS One. It also involved partners at the Federal University of Uberlandia in Minas Gerais, Brazil, the University of Vale do Paraíba in Sao Paolo, Brazil and therefore the University of Saskatchewan in Canada.
Dr. Matthew Baker, a Reader in Strathclyde’s Department of Pure and Applied Chemistry and lead researcher within the project, said: “Frequent monitoring of diabetes is important for improved glucose control and to delay clinical complications associated with the condition. Early screening is additionally paramount in reducing these complications worldwide.
“Blood analysis for screening, monitoring and diagnosing diabetes is widely practiced but is sort of invasive and painful. The constant need of piercing the fingers several times daily for many patients may cause the event of finger calluses, also as difficulty in obtaining blood samples; furthermore, not everyone would want to offer blood and there are circumstances during which it might be dangerous.
“Saliva reflects several physiological functions of the body, like emotional, hormonal, nutritional and metabolic, then its biomarkers might be an alternative to blood for robust early detection and monitoring. it’s easy to gather, non-invasive, convenient to store and requires less handling than blood during clinical procedures, while also being environmentally efficient. It also contains analytes with real-time monitoring value which may be wont to check a person’s condition.”
Dr. Robinson Sabino-Silva, a professor at the Federal University of Uberlandia (UFU) and a partner within the research, said: “The present protocol utilized in the infrared platform is in a position to detect spectral biomarkers without reagents. the mixture of a non-invasive salivary collection and a reagent-free analysis permit us to watch diabetes with a sustainable platform classified as green technology.“
The lab tests used a scientific system referred to as Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. This has been utilized in the diagnosis of several diseases, although its applications within the monitoring of diabetic treatment have begun to emerge only recently. Samples were assessed in three categories – diabetic, non-diabetic and insulin-treated diabetic – and two potential diagnostic biomarkers were identified.
The researchers are hopeful that the method they need to be developed might be used for both Type 1 and sort 2 diabetes, although further study is going to be required to verify this.